Allopurinol riboside

Research use only, not for human use.

Allopurinol riboside is a metabolite of allopurinol with potency against parasites.

Allopurinol riboside is a metabolite of allopurinol with potency against parasites. Allopurinol riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a Ki of 277 μM.(In Vitro):Allopurinol riboside is effective against parasites including leishmaniasis and American trypanosomiasis. Allopurinol riboside is selectively toxic because it is not metabolized by the corresponding enzymes in humans. Humoral immunity is not suppressed by Allopurinol riboside. Lymphocyte blastogenesis induced by PHA and Con A is significantly suppressed by Allopurinol riboside in a concentration-dependent manner.(In Vivo):Low levels of Allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. Probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma. Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 h, and has steady-state concentrations in the therapeutic range.

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Others

Other Targets

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16220-07-8

268.2

C10H12N4O5

>98% (HPLC)

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OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ncc2c1[nH]cnc2=O

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(-20℃)

With Ice Pack

≥ 2 years